Cost-effectiveness analysis comparing intensity-modulated radiotherapy with conformational radiotherapy (3D-RT) for prostate cancer in the brazilian health system

SUMMARY OBJECTIVE: The intensity-modulated radiotherapy (IMRT) has been established as the standard external-beam radiation technique to treat prostate cancer in several countries. In Brazil, public health system and National Health Agency do not reimburse its utilization. This study compared cost-effectiveness of IMRT tridimensional (3D-RT) from a payer’s perspective. METHODS: We built Markov model delineate states after treatment with 3D-RT. treatment-related toxicity data were extracted literature. sensitivity analyses performed over potential parameters. RESULTS: incremental cost was R$ 5,553.78. At time horizon 5 years, quality-adjusted life expectancy higher than ratio (ICER) 3D-RT R$-296,74/quality-adjusted year (QALY). Therefore, dominant strategy, which depended on value interventional procedures for severe difference between reimbursement. still most likely be cost-effective at willingness-to-pay 100,000/QALY, net monetary benefit (NMB) superior 50,000.00, resulting R$220.000,00 years. CONCLUSIONS: generated more values treatment. Given reduce late hypofractionation, these reinforce incorporation Brazilian